Synthetic cytokine genes
for targeted immune modulation
Expression-optimized (*) or wild type cytokine genes of murine and human origin for in vitro and in vivo applications as molecular adjuvant for DNA vaccine, gene therapy and related applications.
Cytokines represent a sophisticated network of early soluble mediators secreted by cells that are involved in the regulation of host defense. Naturally occurring nucleotdide sequences warrant the cytokine function as a short-lived mediator by containing instability motives to enable a fast degradation of the messenger RNA.
GENEART's technology prodvides solutions for a stabilization of the RNA and for increased protein yields for an optimal experimental and therapeutic setting in your immunological approach.
Please use our online request form to obtain a quote for your specific project. Cloned expression constructs also on request.
| Construct | Origin | Gene | Product no. | Price |
| B-7.1 | murine | wt standard | 851012 | € 300 |
| superopt* standard | 851013 | € 595 | ||
| GM-CSF | human | wt standard | 851000 | € 300 |
| superopt* standard | 851001 | € 595 | ||
| murine | wt standard | 851002 | € 300 | |
| superopt* standard | 851003 | € 595 | ||
| IL-2 | human | superopt* standard | 851016 | € 595 |
| murine | superopt* standard | 851018 | € 595 | |
| IL-6 | human | superopt* standard | 851024 | € 595 |
| murine | superopt*standard | 851026 | € 595 | |
| IL-7 | murine | superopt* standard | 851037 | € 595 |
| IL-12 | human | superopt* standard | 851028 | € 595 |
| murine | superopt* standard | 851030 | € 595 | |
| IL-15 | human | wt standard | 851006 | € 300 |
| superopt* standard | 851007 | € 595 | ||
| murine | wt standard | 851004 | € 300 | |
| superopt* standard | 851005 | € 595 | ||
| INFgamma | human | superopt* standard | 851032 | € 595 |
| murine | superopt* standard | 851034 | € 595 | |
| MIP-1alpha | human | wt standard | 851008 | € 300 |
| superopt* standard | 851009 | € 595 | ||
| murine | wt standard | 851010 | € 300 | |
| superopt* standard | 851011 | € 595 |
*High yield expression optimized genes
The purchase of this gene conveys to the buyer the non-transferable right to use the purchased gene as stated bellow: This gene is high yield expression optimized by a special optimization technology subject of the filed patent DE 102004037652.2 and other German and foreign patent applications owned by GENEART AG. The gene is sold and transferred for research and development purposes only and not for commercial purposes. Commercial purposes means any activity by a party for consideration and may include, but is not limited to: (1) use of the genes or its components in manufacturing; (2) use of the genes or its components for therapeutic, diagnostic or prophylactic purposes; (3) use of the genes or its components to provide a service, information, or data; or (4) resale of the genes or its components, whether or not such gene or components are resold for use in research. For information on purchasing a license to use these genes for purposes other than those permitted above, contact Business Development, GENEART AG, Josef-Engert-Str. 11, 93053 Regensburg, Germany. Phone +49-(0)941-942760.
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